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Updated: Dec 31, 2025

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
Biaryl Monophosphine Ligands in Palladium-Catalyzed C-N Coupling: An Updated User's Guide
Bryan T Ingoglia1, Corin C Wagen1, Stephen L Buchwald1
1Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, United States.
Abstract:
Over the past three decades, Pd-catalyzed cross-coupling reactions have become a mainstay of organic synthesis. In particular, catalysts derived from biaryl monophosphines have shown wide utility in forming C-N bonds under mild reaction conditions. This work summarizes a variety of C-N cross-coupling reactions using biaryl monophosphines as supporting ligands, with the goal of directing synthetic chemists towards the ligands and conditions best suited for a particular coupling.
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