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Neurosurgical infection treated with fosfomycin and 6-methylprednisolone
Chemotherapy
|January 1, 1977
Abstract:
A left parietal parasagittal meningioma was removed in a 67-year-old female patient. In the postoperative period she had a neurosurgical cerebral suppurating infection: subdural, epidural and epicranial, connected to the exterior by several fistulas. In the operative revision and after a culture, the germ causing the infection, E. coli, was isolated. Treatment was begun with 16 g of intravenous fosfomycin and 120 mg daily of 6-methylprednisolone intramuscularly, and this treatment cured the patient.
Insights
A rare postoperative brain infection caused by E. coli was successfully treated. The patient recovered fully after receiving intravenous fosfomycin and 6-methylprednisolone.
Area of Science:
- Neurosurgery
- Infectious Diseases
- Pharmacology
Background:
- Postoperative complications following meningioma resection can include serious infections.
- Cerebral suppurating infections require prompt diagnosis and effective treatment strategies.
Observation:
- A 67-year-old female developed subdural, epidural, and epicranial infections post-left parietal parasagittal meningioma removal.
- The infection was connected to the exterior via multiple fistulas.
- Operative revision and microbial culture identified Escherichia coli (E. coli) as the causative agent.
Findings:
- Intravenous fosfomycin (16 g daily) combined with intramuscular 6-methylprednisolone (120 mg daily) effectively treated the extensive postoperative infection.
- The patient achieved a complete recovery without further complications.
Implications:
- This case highlights the efficacy of fosfomycin and corticosteroids in managing severe, multidomain postoperative neurosurgical infections.
- Early identification of the pathogen and aggressive treatment are crucial for favorable outcomes in such cases.
- Fosfomycin presents a viable therapeutic option for multidrug-resistant bacterial infections in neurosurgery.