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Automated Quantification of Hematopoietic Cell – Stromal Cell Interactions in Histological Images of Undecalcified Bone
Published on: April 8, 2015
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Bone: a key aspect to understand phenomena in clinical hematology
Kanako Wakahashi1, Yoshio Katayama2
1Hematology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
Journal of Bone and Mineral Metabolism
|January 4, 2020
Summary
Bone and blood cell systems communicate, with disruptions potentially causing blood disorders. The vitamin D receptor is key to this bone-marrow network and myelofibrosis.
Area of Science:
- Bone biology
- Hematology
- Endocrinology
Background:
- Bone marrow (BM) resides within bone, and bone tissue communicates with the BM hematopoietic system.
- Osteoblast cells create a microenvironment for immature hematopoietic cells.
- Mature cells like neutrophils and macrophages regulate osteoblast activity.
Purpose of the Study:
- To investigate the functional communication between bone and the hematopoietic system.
- To explore the role of this inter-organ network in hematologic disorders.
- To elucidate the involvement of the vitamin D receptor in myelofibrosis pathogenesis.
Main Methods:
- Literature review of recent studies on bone-hematopoietic system interactions.
- Analysis of the role of osteoblast and hematopoietic cells in inter-organ communication.
- Examination of the vitamin D receptor's function in the bone-marrow network.
Main Results:
- Bone and hematopoietic systems exhibit functional communication.
- Distorted communication can lead to hematologic disorders.
- The vitamin D receptor acts as a crucial link in this network and in myelofibrosis.
Conclusions:
- The intricate communication between skeletal and hematopoietic systems is vital.
- Dysregulation of this crosstalk contributes to hematologic diseases.
- The vitamin D receptor is a significant factor in the pathogenesis of myelofibrosis.
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