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Treatment of cefazolin in 45 cases of urinary tract infections
Abstract:
We have treated 45 cases of urinary tract infection with cefazolin (i.m.) and cure was achieved in 35 (77.77%). 26 of the 28 patients (92.85%) with acute cystitis who received 250 mg every 12 h for 6-10 days were cured. 17 patients with pyelonephritis received 500 mg every 12 h during 10-14 days and therapeutical success was achieved in 9 of them (52.94%). Laboratory control was carried out at the initiation of therapy, at the end, and 1 month after therapy. Tolerance to injections of cefazolin was considered good and only in one case appeared a mild eosinophia.
Insights
Cefazolin injections effectively treated urinary tract infections, with high cure rates for acute cystitis (92.85%) but lower success in pyelonephritis (52.94%). This antibiotic demonstrated good tolerance in patients.
Area of Science:
- Clinical Medicine
- Infectious Diseases
- Pharmacology
Background:
- Urinary tract infections (UTIs) are common bacterial infections requiring effective antibiotic treatment.
- Cefazolin is a first-generation cephalosporin antibiotic with established efficacy against various bacterial pathogens.
Purpose of the Study:
- To evaluate the therapeutic efficacy and tolerance of intramuscular cefazolin in patients with urinary tract infections.
- To assess treatment outcomes for different UTI classifications, specifically acute cystitis and pyelonephritis.
Main Methods:
- A prospective study involving 45 patients diagnosed with UTIs.
- Patients received intramuscular cefazolin at varying dosages and durations based on UTI severity.
- Clinical and laboratory monitoring was conducted at baseline, end of therapy, and one month post-treatment.
Main Results:
- An overall cure rate of 77.77% (35 out of 45 patients) was observed.
- Acute cystitis patients treated with 250 mg every 12 hours for 6-10 days achieved a high cure rate of 92.85% (26 out of 28).
- Pyelonephritis patients receiving 500 mg every 12 hours for 10-14 days had a lower success rate of 52.94% (9 out of 17).
- Cefazolin demonstrated good tolerance, with only one case of mild eosinophilia reported.
Conclusions:
- Intramuscular cefazolin is an effective treatment for urinary tract infections, particularly acute cystitis.
- Dosage and duration adjustments may be necessary for optimal outcomes in more severe infections like pyelonephritis.
- Cefazolin is well-tolerated, making it a viable therapeutic option for UTIs.