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Genetically Encoded Activators of Small Molecules for Imaging and Drug Delivery
Zacharias Thiel1,2, Jade Nguyen1,2, Pablo Rivera-Fuentes1
1Institute of Chemical Sciences and Engineering, EPF Lausanne, CH C2 425, Station 6, 1015, Lausanne, Switzerland.
Abstract:
Chemical biologists have developed many tools based on genetically encoded macromolecules and small, synthetic compounds. The two different approaches are extremely useful, but they have inherent limitations. In this Minireview, we highlight examples of strategies that combine both concepts to tackle challenging problems in chemical biology. We discuss applications in imaging, with a focus on super-resolved techniques, and in probe and drug delivery. We propose future directions in this field, hoping to inspire chemical biologists to develop new combinations of synthetic and genetically encoded probes.
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