OPTN/SRTR 2018 Annual Data Report: Intestine

Area of Science:

• Transplantation Medicine
• Gastroenterology
• Surgical Innovation

Background:

• Intestine transplantation is a vital treatment for intestinal failure.
• Despite advances, organ availability and procedure numbers have decreased.
• Graft failure rates have stabilized in recent years.

Purpose of the Study:

• To analyze trends in intestine transplantation over the past decade.
• To evaluate patient survival rates based on age and transplant type.
• To highlight the current status and outcomes of intestine transplant procedures.

Main Methods:

• Retrospective analysis of intestine transplant waiting list data.
• Review of donor statistics and number of procedures performed.
• Survival analysis stratified by patient age and transplant type (intestine vs. intestine-liver).

Main Results:

• A significant decline in new patients added to the waiting list and available donors was observed by 2018.
• The total number of intestine transplants performed reached a decade low in 2018, with 59% being combined intestine-liver transplants.
• Patient survival rates varied, with 1- and 5-year survival at 66.7% and 49.1% for adult intestine-liver recipients, versus 89.1% and 76.4% for pediatric intestine recipients.

Conclusions:

• Intestine transplantation continues to be an important therapeutic option for intestinal failure.
• Declining donor and recipient numbers pose challenges to the field.
• Pediatric intestine recipients demonstrate superior survival outcomes compared to adult combined intestine-liver recipients.