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Related Concept Videos

Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...

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A Protocol for Analyzing Hepatitis C Virus Replication
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Published on: June 26, 2014

OPTN/SRTR 2018 Annual Data Report: Hepatitis C.

J H Wang1, S K Gustafson2, M A Skeans2

  • 1Department of Medicine, Hennepin Healthcare, University of Minnesota, Minneapolis, MN.

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
|January 4, 2020
PubMed
Summary

Direct acting antivirals (DAAs) enable the use of hepatitis C virus (HCV)-infected organs for transplantation. While short-term outcomes are promising, long-term allograft survival requires further investigation.

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Area of Science:

  • Transplantation immunology
  • Infectious disease
  • Organ transplantation

Background:

  • Direct acting antivirals (DAAs) have revolutionized hepatitis C virus (HCV) treatment.
  • DAAs offer high cure rates post-transplant, increasing interest in HCV-positive donor organs.
  • This has led to increased transplantation of organs from HCV-positive donors into both HCV-infected and uninfected recipients.

Purpose of the Study:

  • To examine trends in HCV-positive donor transplants from 2007 to 2018 across various organ types.
  • To analyze changes in willingness to accept HCV-positive organs among transplant candidates.
  • To assess short-term and long-term allograft survival rates for recipients of HCV-positive organs.

Main Methods:

  • Analysis of transplant data from 2007 to 2018.
  • Examination of trends in organ acceptance and transplant numbers.
  • Comparison of allograft survival rates between recipients of HCV-positive and HCV-negative donor organs.

Main Results:

  • Willingness to accept HCV-positive organs increased for kidney, lung, heart, and pancreas transplants since 2015.
  • Willingness decreased for intestine transplants and initially for liver transplants, with a recent increase.
  • Numbers of HCV-positive donor kidney, heart, lung, and liver transplants have risen significantly.
  • Short-term allograft survival for kidney and liver transplants using HCV-positive organs appears comparable to those using HCV-negative organs.
  • Unadjusted analysis suggests potentially worse long-term allograft survival for HCV-positive donor organs.
  • Emerging data on kidney transplants from HCV-infected donors to uninfected recipients with DAA treatment show promising short-term survival.

Conclusions:

  • The use of HCV-positive donor organs is increasing, driven by DAA advancements.
  • Short-term allograft survival is comparable, but long-term outcomes require further study.
  • Kidney transplantation from HCV-infected donors to uninfected recipients with post-transplant DAA treatment is a promising area needing long-term monitoring.