Related Experiment Video

Updated: Dec 31, 2025

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis
07:26

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis

Published on: January 31, 2025

947

Sonic hedgehog signaling in epithelial tissue development

Lu Zheng1, Chen Rui1, Hao Zhang1

  • 1Central Lab of Biomedical Research Center, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, PR China.

Regenerative Medicine Research
|January 4, 2020
PubMed

Insights

The Sonic hedgehog (SHH) signaling pathway is crucial for development and regeneration. Understanding SHH molecules offers insights into tissue repair and treating diseases linked to its pathway dysfunction.

Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Regenerative Medicine

Background:

  • The Sonic hedgehog (SHH) signaling pathway plays a vital role in embryonic development and tissue regeneration.
  • Dysregulation of the SHH pathway is implicated in various diseases, including cancers and birth defects.

Purpose of the Study:

  • To review recent studies on key molecules within the SHH signaling pathway.
  • To focus on the function of these molecules in the development of epithelial tissues and appendages.

Main Methods:

  • Literature review of recent studies on the SHH signaling pathway.
  • Analysis of molecular functions in epithelial and appendage development.

Main Results:

  • Detailed examination of SHH pathway molecules' roles in epidermis, hair, glands, teeth, nails, and gastrointestinal epithelia.
  • Identified specific molecular mechanisms governing development and regeneration.

Conclusions:

  • Advances in understanding the SHH pathway provide crucial insights into tissue repair and regeneration mechanisms.
  • This knowledge can guide the development of novel therapeutic strategies for SHH-related diseases.
Keywords:
Sonic hedgehogepidermisgastric epitheliumintestinal epitheliummammary glandskin appendages

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