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Recent developments in nitric oxide-releasing biomaterials for biomedical applications
Han Yu1, Lin-Xian Cui2, Nan Huang1
1Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan Province, China.
Medical Gas Research
|January 4, 2020
Summary
This review highlights recent advancements in nitric oxide (NO) releasing biomaterials. Novel strategies focus on controlled NO delivery for enhanced cardiovascular and anticancer therapies, overcoming limitations of current prodrugs.
Area of Science:
- Biomaterials Science
- Medical Gas Therapy
- Drug Delivery Systems
Background:
- Nitric oxide (NO) is an endogenous gas with vital physiological roles, including anti-inflammatory, anti-cancer, and cardiovascular effects.
- Biomaterials designed to release NO are gaining attention for therapeutic applications, but current prodrugs face challenges with low payload and uncontrolled release.
- Existing NO-releasing devices often fail to meet expectations due to limitations in delivery efficiency and control.
Purpose of the Study:
- To review recent (3-year) progress in developing advanced NO-releasing biomaterials.
- To explore innovative strategies for controlled nitric oxide delivery in therapeutic settings.
- To address the limitations of existing NO-releasing prodrugs and devices.
Main Methods:
- Review of recent scientific literature focusing on NO-releasing biomaterials.
- Analysis of strategies including endothelial-mimicking coatings for atherosclerosis treatment.
- Examination of nanocarriers for sustained NO release in anticancer therapy.
- Investigation of prodrug modification for stable cardiovascular stents and targeted anticancer drug delivery.
Main Results:
- Development of coatings that mimic vascular endothelium for atherosclerosis management.
- Design of nanocarriers enabling sustained nitric oxide generation for effective anticancer treatment.
- Engineering of stable cardiovascular stents and targeted anticancer drugs through prodrug modification.
Conclusions:
- Recent innovations show promise in overcoming NO delivery challenges.
- Advanced biomaterials offer improved control and efficacy for NO-based therapies.
- Future applications include enhanced cardiovascular treatments and targeted cancer therapies using NO-releasing systems.
