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Preoperative predictors of pelvic and para-aortic lymph node metastases in cervical cancer
Varol Gulseren1, Mustafa Kocaer2, Ozgu Gungorduk3
1Department of Obstetrics and Gynecology, Kaman State Hospital, Kırşehir, Turkey.
Aim:
This study investigated potential preoperative predictors of pelvic lymph node (PLN) and para-aortic LN (PaLN) involvement in cervical cancer (CC).
Materials And Methods:
This study retrospectively analyzed 283 patients diagnosed with early (stage IA1-IIA) CC who underwent retroperitoneal LN dissection between January 1992 and February 2015. Several risk factors that are believed to influence PLN and PaLN involvement in CC were analyzed as follows: age >50 years, lymphovascular space invasion (LVSI), tumor size ≥2 cm, hemoglobin <12 g/dL, and nonsquamous cell histologic type.
Results:
LVSI (odds ratio [OR] = 11.3, 95% confidence interval [CI] = 5.2-24.3) and tumor size (OR = 3.2, 95% CI = 1.4-7.2) were independent predictors of PLN involvement. None of the factors predicted PaLN involvement in a regression analysis. However, all nine patients who had PaLN involvement also had PLN involvement.
Conclusion:
LVSI and tumor size independently increase the risk of PLN involvement.
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