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Related Concept Videos

Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
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Drug release from modified-release dosage forms is designed to achieve specific therapeutic effects by controlling the rate and extent of drug release. The classification of these drug release systems is based on key pharmacokinetic assumptions: drug disposition follows first-order kinetics, drug release is the rate-limiting step in absorption, and the released drug is rapidly and completely absorbed.There are four major models of drug release patterns. The first model is the slow zero-order...
Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

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Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

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Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...

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Nanoporous hybrid core-shell nanoparticles for sequential release.

Mandy Jahns1, Dawid Peter Warwas2, Marc Robert Krey2

  • 1Institute for Inorganic Chemistry, Gottfried Wilhelm Leibniz University Hannover, 30167 Hannover, Germany. peter.behrens@acb.uni-hannover.de and Cluster of Excellence Hearing4all, Hannover, Germany.

Journal of Materials Chemistry. B
|January 4, 2020
PubMed
Summary
This summary is machine-generated.

This study introduces novel non-metal core-shell nanoparticles with porous silica cores and organosilica shells. These engineered nanoparticles enable selective molecule adsorption and sustained, sequential drug release over extended periods.

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Chemical Engineering

Background:

  • Existing core-shell nanoparticles often utilize metal components.
  • There is a need for advanced nanomaterials with tailored properties for controlled release applications.

Purpose of the Study:

  • To synthesize and characterize novel non-metal core-shell nanoparticles.
  • To demonstrate the selective adsorption and sequential release capabilities of these nanoparticles for guest molecules and drugs.

Main Methods:

  • Synthesis of core-shell nanoparticles using nanoporous silica nanoparticles (NPSNPs) coated with nanoporous phenylene-bridged organosilica.
  • Characterization of particle diameter (~80 nm) and chemical properties.
  • Loading and release experiments using model guest molecules (dyes) and drugs with varying polarity and charge.

Main Results:

  • Successful synthesis of non-metal core-shell nanoparticles with distinct hydrophilic (silica core) and hydrophobic (organosilica shell) regions.
  • Demonstrated selective adsorption based on molecular charge and polarity.
  • Achieved sustained, sequential release of molecules, with dyes and drugs released over extended periods (over one year for dyes).

Conclusions:

  • The developed non-metal core-shell nanoparticles offer unique properties for selective guest molecule interactions.
  • These nanoparticles show significant potential for controlled and sustained sequential release of pharmaceuticals.
  • The engineered nanostructure provides a tunable diffusion barrier for precise release kinetics.