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Related Concept Videos

Embryonic Stem Cells00:57

Embryonic Stem Cells

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
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Embryonic Stem Cells00:58

Embryonic Stem Cells

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Adult Stem Cells01:33

Adult Stem Cells

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Stem Cell Niche01:26

Stem Cell Niche

6.1K
The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
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Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Related Experiment Video

Updated: Dec 31, 2025

Growing Neural Stem Cells from Conventional and Nonconventional Regions of the Adult Rodent Brain
11:27

Growing Neural Stem Cells from Conventional and Nonconventional Regions of the Adult Rodent Brain

Published on: November 18, 2013

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Neural Stem Cells.

Julian P Tuazon1, Vanessa Castelli1, Jea-Young Lee1

  • 1Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, FL, USA.

Advances in Experimental Medicine and Biology
|January 4, 2020
PubMed
Summary
This summary is machine-generated.

Neural stem cell (NSC) transplantation shows promise for treating stroke, psychiatric disorders, and cancer. Further research is needed to overcome barriers for effective clinical application of these cell-based therapies.

Keywords:
CancerClinical researchFetal alcohol spectrum disordersGraftNeural stem cellPreclinical researchStem cell therapyStroke

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Last Updated: Dec 31, 2025

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Enumeration of Neural Stem Cells Using Clonal Assays
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Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Cell Therapy

Background:

  • Neural stem cells (NSCs) offer potential therapeutic strategies for various diseases.
  • Preclinical studies explore NSC applications in stroke, fetal alcohol spectrum disorders, and cancer.

Purpose of the Study:

  • To review preclinical investigations of NSC transplantation.
  • To identify barriers and future directions for NSC-based therapies.

Main Methods:

  • Discussion of preclinical research findings.
  • Analysis of translational requirements for clinical application.

Main Results:

  • NSCs demonstrate potential to ameliorate disease conditions.
  • Significant translational hurdles remain for clinical use.

Conclusions:

  • Optimizing dosing, delivery, and timing are crucial.
  • Understanding the precise mechanisms of NSC-mediated recovery is essential for refining therapies.