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A Reliable Porcine Fascio-Cutaneous Flap Model for Vascularized Composite Allografts Bioengineering Studies

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Hyperoxygenated solution improves tissue viability in an avulsion injury flap model.

Jianzhang Wang¹, Zhangqiang Tuo¹, Juan Zhang¹

¹Department of Plastic and Reconstructive Surgery, Xijing Hospital, Fourth Military Medical University, No.127 Changle West Road, Xi'an, Shanxi Province 710032, People's Republic of China.

Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS

|January 4, 2020

Summary

Hyperoxygenated solution (HOS) effectively improved avulsion injury flap survival in rats. This treatment increased local oxygen levels and blood perfusion, while reducing inflammation for better outcomes.

Keywords:

Avulsion injury Blood microcirculation Experimental model Hyperoxygenated solution

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Area of Science:

Regenerative Medicine
Tissue Engineering
Experimental Surgery

Background:

Avulsion injuries pose significant challenges in clinical management due to high rates of necrosis.
Developing reliable experimental models is crucial for investigating novel therapeutic strategies.

Purpose of the Study:

To establish a rat model for skin avulsion injuries.
To evaluate the efficacy of hyperoxygenated solution (HOS) in improving flap survival following avulsion injury.

Main Methods:

A standardized skin avulsion injury model was created in male rats.
Animals received daily intravenous HOS or saline for seven days post-injury.
Key assessments included percutaneous oxygen pressure (TcpO2), flap blood perfusion, survival rates, and histopathology.

Main Results:

HOS administration significantly increased TcpO2 levels and flap blood perfusion compared to saline controls.
The survival rate of avulsion flaps was markedly higher in the HOS-treated group.
Histopathological analysis corroborated the beneficial effects of HOS on tissue viability and inflammation.

Conclusions:

A reproducible rat model for avulsion injury was successfully developed.
Hyperoxygenated solution demonstrates significant potential in enhancing avulsion injury flap survival.
HOS improves flap viability by increasing oxygenation, enhancing perfusion, and mitigating inflammatory damage.