[Small fibre neuropathy: A review].

Area of Science:

• Neurology
• Peripheral Nervous System Disorders

Background:

• Small fibre neuropathy (SFN) is a peripheral nervous system disorder.
• It primarily impacts small myelinated (Aδ) and non-myelinated (C) nerve fibres.
• Clinical manifestations include chronic neuropathic pain and autonomic nervous system alterations.

Purpose of the Study:

• To highlight the diagnostic challenges of small fibre neuropathy.
• To emphasize the importance of recognizing SFN for timely diagnosis and treatment.
• To discuss the primary and secondary causes of SFN.

Main Methods:

• Routine neurophysiological tests are often negative in SFN.
• Diagnostic confirmation relies on specialized tests like microneurography and sensory stimulation tests.
• Skin biopsy is a commonly utilized diagnostic technique.

Main Results:

• SFN presents with diverse symptoms, complicating diagnosis.
• Standard neurophysiological assessments lack sensitivity for SFN.
• Advanced diagnostic methods are crucial for identifying the condition.

Conclusions:

• Early clinical suspicion and awareness of SFN are vital.
• Access to specialized diagnostic tools is essential, especially from Primary Health Care.
• Treatment targets both the underlying causes and neurological symptoms of SFN.