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Related Experiment Video

Updated: Dec 31, 2025

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice
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PedsQL™ Cognitive Functioning Scale in youth with epilepsy: Reliability and validity.

James W Varni1, Katherine F Junger2, Tanja Kellermann3

  • 1Department of Pediatrics, College of Medicine, Texas A&M University, College Station, TX, USA; Department of Landscape Architecture and Urban Planning, College of Architecture, Texas A&M University, College Station, TX, USA.

Epilepsy & Behavior : E&B
|January 4, 2020
PubMed
Summary
This summary is machine-generated.

The Pediatric Quality of Life Inventory™ (PedsQL™) Cognitive Functioning Scale is a reliable and valid brief measure for assessing cognitive function in youth with epilepsy. This scale is suitable for clinical research and practice in pediatric epilepsy.

Keywords:
Cognitive functioningEpilepsyExecutive functioningPatient-reported outcomesPediatricsPedsQL

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Area of Science:

  • Pediatric Neurology
  • Psychometrics
  • Quality of Life Measurement

Background:

  • Cognitive functioning is a critical aspect of quality of life for youth with epilepsy.
  • Brief, reliable, and valid measures are needed to assess cognitive function in this population.
  • The Pediatric Quality of Life Inventory™ (PedsQL™) Cognitive Functioning Scale is a potential tool for this purpose.

Purpose of the Study:

  • To evaluate the internal consistency reliability and validity (discriminant, concurrent, construct) of the PedsQL™ Cognitive Functioning Scale.
  • To assess its suitability as a brief generic cognitive functioning measure in youth with epilepsy.

Main Methods:

  • The PedsQL™ Cognitive Functioning Scale (6 items) and PedsQL™ 4.0 Generic Core Scales (23 items) were administered to 221 pediatric patients with epilepsy (ages 5-18).
  • Parents of these patients (ages 2-18) also completed the Behavior Rating Inventory of Executive Function (BRIEF) (86 items).
  • A national field test study was conducted for the PedsQL™ Epilepsy Module.

Main Results:

  • The PedsQL™ Cognitive Functioning Scale demonstrated excellent internal consistency reliability (patient self-report α=0.88; parent proxy-report α=0.96).
  • It showed strong discriminant validity, distinguishing between youth with epilepsy and healthy controls (large effect sizes).
  • Concurrent and construct validity were supported by significant correlations with the BRIEF and PedsQL™ Generic Core Scales (rs=0.43-0.74, P<0.001).

Conclusions:

  • The PedsQL™ Cognitive Functioning Scale exhibits excellent reliability and validity in youth with epilepsy.
  • It is a suitable brief, generic patient-reported outcome (PRO) measure for pediatric epilepsy research and clinical practice.
  • The scale aids in assessing cognitive function and informing clinical decisions in pediatric epilepsy management.