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Antimicrobial properties of benzalkonium chloride derived polymerizable deep eutectic solvent
Jing Wang1, Jing Xue2, Xiaoqing Dong3
1School of Chemistry and Chemical Engineering, Shandong University of Technology, Zibo, Shandong, China; Department of Mechanical & Aerospace Engineering, University of Missouri, Columbia, MO, United States.
International Journal of Pharmaceutics
|January 4, 2020
Summary
Benzalkonium chloride (BC) was formulated into deep eutectic solvents (DES) with acrylic acid or methacrylic acid for enhanced antimicrobial properties. The resulting DES showed strong effectiveness against bacteria and fungi, offering potential for new antimicrobial materials.
Area of Science:
- Materials Science
- Antimicrobial Agents
- Polymer Chemistry
Background:
- Benzalkonium chloride (BC) is a widely used quaternary ammonium antimicrobial agent.
- Deep eutectic solvents (DES) offer unique properties for material formulation.
- Developing novel antimicrobial materials with controlled release is of significant interest.
Purpose of the Study:
- To prepare benzalkonium chloride (BC) into deep eutectic solvents (DES) with acrylic acid (AA) and methacrylic acid (MA).
- To evaluate the antimicrobial efficacy of the synthesized BC-DES formulations against E. coli, S. aureus, and C. albicans.
- To investigate the influence of polymerization on antimicrobial performance and material properties.
Main Methods:
- Preparation of BC-AA DES and BC-MA DES.
- Antimicrobial activity assessment using the agar diffusion test.
- Viscosity measurements and polymerization studies of DES.
- Analysis of inhibition zone widths and activation energy.
Main Results:
- BC-AA DES demonstrated enhanced antimicrobial effectiveness against S. aureus and C. albicans.
- Polymerized BC-AA DES showed smaller inhibition zones compared to the monomer, indicating limited active component transport.
- Methacrylic acid (MA) incorporation resulted in reduced inhibition zones, potentially due to increased structural complexity and decreased linearity.
Conclusions:
- The study successfully prepared BC-based DES with antimicrobial properties.
- Polymerization of DES can affect antimicrobial release and effectiveness.
- Optimizing the eutectic ratio of DES is crucial for controlled drug release and enhanced antimicrobial material design.
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