Related Experiment Video

Updated: Dec 31, 2025

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as A Novel Detection and Quantification Method
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MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as A Novel Detection and Quantification Method

Published on: October 7, 2025

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microRNA-181 serves as a dual-role regulator in the development of human cancers

Tayebeh Rezaei1, Mohammad Amini2, Zahra Sadat Hashemi3

  • 1Department of Biology, Higher Education Institute of Rab-Rashid, Tabriz, Iran; Department of Molecular Medicine and Biotechnology, Faculty of Medicine, Arak University of Medical Science, Arak, Iran.

Free Radical Biology & Medicine
|January 4, 2020
PubMed

Insights

MicroRNAs (miRNAs) are key regulators in cellular processes. The miR-181 family shows dysregulation in cancers, acting as oncomirs or tumor suppressors, offering potential diagnostic and therapeutic targets.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • MicroRNAs (miRNAs) are short noncoding RNAs regulating gene expression.
  • miRNA dysfunction is linked to cancer development via signaling pathways.
  • The miR-181 family is frequently dysregulated in various human cancers.

Purpose of the Study:

  • To review the multifaceted roles of the miR-181 family in tumorigenesis.
  • To highlight the miR-181 family's involvement in key cancer hallmarks.
  • To explore the potential of miR-181 as cancer biomarkers and therapeutic targets.

Main Methods:

  • Literature review of recent studies on the miR-181 family in cancer.
  • Analysis of miRNA-mediated regulation of signaling pathways (e.g., PI3K/AKT, MAPK).
  • Examination of miR-181's role in cell proliferation, apoptosis, autophagy, angiogenesis, and drug resistance.

Main Results:

  • The miR-181 family acts as both oncogenic and tumor-suppressive, depending on context.
  • Dysregulation of miR-181 impacts multiple cancer-related cellular processes.
  • miR-181 family members modulate critical signaling pathways implicated in cancer progression.

Conclusions:

  • The miR-181 family plays a pivotal role in cancer development and progression.
  • These miRNAs represent promising diagnostic and prognostic biomarkers.
  • Targeting the miR-181 family offers potential therapeutic strategies for human cancers.
Keywords:
BiomarkerCancerSignaling pathwaymiR-181 family

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