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Updated: Dec 31, 2025
12:03
Receptor Autoradiography Protocol for the Localized Visualization of Angiotensin II Receptors
Published on: June 7, 2016
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Angiotensin receptor subtypes regulate adipose tissue renewal and remodelling
Pyotr A Tyurin-Kuzmin1, Natalia I Kalinina1, Konstantin Y Kulebyakin1
1Department of Biochemistry and Molecular Medicine, Faculty of Medicine, Lomonosov Moscow State University, Russia.
The FEBS Journal
|January 4, 2020
Summary
The renin-angiotensin system (RAS) regulates adipose tissue renewal. Angiotensin II type 2 receptor (AT2R) plays a key role in adipose-derived mesenchymal stem/stromal cell (ADSC) differentiation and hormonal sensitivity.
Area of Science:
- Adipose tissue biology
- Stem cell research
- Endocrinology
Background:
- Obesity is linked to high renin-angiotensin system (RAS) activity in adipose tissue.
- Adipose-derived mesenchymal stem/stromal cells (ADSCs) drive adipose tissue expansion during obesity.
- ADSCs express multiple angiotensin II receptor isoforms, including AT1R and AT2R, leading to complex cellular responses.
Purpose of the Study:
- To review the regulation of adipose tissue renewal by RAS.
- To emphasize the role of AT2R in ADSC adipogenic differentiation and secretory activity.
- To present a novel mechanism involving AT2R in ADSC hormonal sensitivity.
Main Methods:
- Review of current scientific literature on RAS and ADSCs.
- Analysis of angiotensin II receptor expression and function in ADSCs.
- Investigation of AT2R heteromerization with other receptors.
Main Results:
- AT1R activation on ADSCs leads to transient effects due to receptor internalization.
- AT2R heteromerization with AT1R prevents rapid internalization, prolonging cellular effects.
- AT2R is crucial for regulating ADSC differentiation, secretory activity, and beige adipocyte generation.
Conclusions:
- RAS significantly influences adipose tissue renewal and ADSC functions.
- AT2R plays a critical regulatory role in ADSC adipogenesis and secretion.
- AT2R is implicated in modulating ADSC hormonal sensitivity, offering new therapeutic targets.
Keywords:
adipogenic differentiationadipose tissueangiotensin IIangiotensin receptor 1angiotensin receptor 2mesenchymal stem cellsMore Related Videos
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