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Updated: Dec 31, 2025

Investigating Intestinal Inflammation in DSS-induced Model of IBD
Published on: February 1, 2012
A comparative study of the nature and magnitude of problems sleeping in inflammatory bowel disease (IBD) compared to
Alexander J Scott1, Olivia Flowers1, Georgina Rowse2
1The School of Health and Related Research (ScHARR), University of Sheffield , Sheffield, UK.
Abstract:
Inflammatory Bowel Disease (IBD) is commonly associated with poor global sleep quality, and has been posited as a modifiable determinant of IBD related outcomes. However, there is little evidence on the specific types of problems sleeping (e.g., sleep apnea, insomnia etc.) that might characterize the poor sleep quality experienced by those with IBD. The present research aimed to investigate the severity of seven specific types of problems sleeping in those with IBD vs. a healthy control group. This cross sectional comparison study recruited N = 409 with IBD, and N = 377 healthy controls. The Sleep-50 questionnaire was used to assess the presence of seven type of problems sleeping. Multivariate Analysis of Covariance (MANCOVA) was used to compare the severity of sleep disturbances between the IBD and control groups. Those in the IBD group reported significantly more severe experiences of five of the seven domains of the sleep-50, including increased; sleep apnea, insomnia, narcolepsy, restless-legs, and nightmares. More research is needed to; (i) improve the identification and treatment of problems sleeping in routine care; (ii) understand the mechamism(s) of action that links problems sleeping to IBD realted outcomes; and (iii) develop adapted interventions to improve sleep in those with IBD.
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