Two Cases of Interleukin-7-Deficient Generalized Verrucosis
Hideyuki Kosumi1, Ken Natsuga1, Shota Takashima1
1Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Abstract:
We report 2 generalized verrucosis (GV) patients homozygous for a novel mutation in the start codon of IL7. Unlike the previous report in which IL-7 deficiency accompanied CD4 T lymphocytopenia, circulating CD4 T cells were not depleted in one of our patients, suggesting a GV pathogenesis other than poor T-cell development.
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