Related Experiment Video
Updated: Dec 31, 2025
Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery
Published on: July 5, 2021
Quality of life considerations for patients with anterior and central skull base malignancies
Christopher W Noel1,2, John R de Almeida3,4
1Department of Otolaryngology-Head and Neck Surgery, Princess Margaret Cancer Centre- University Health Network, Faculty of Medicine, University of Toronto, 610 University Avenue, 3-955, Toronto, ON, M5G 2M9, Canada.
Introduction:
The extirpation of skull base malignancies may be associated with significant morbidity and can profoundly impact health related quality of life (HRQOL). In this review, we sought to provide an overview of HRQOL and the factors that influence it for patients with skull base malignancies.
Materials And Methods:
Narrative review.
Results:
HRQOL tends to improve in the months to years following treatment and is profoundly impacted by both tumor location and treatment approach. Wherever possible, HRQOL should always be elicited from the patient directly. Several HRQOL instruments have been used in this population including generic, site-specific and disease specific measures.
Conclusion:
Given that HRQOL is a multidimensional concept with several important facets, validated disease-specific instruments are generally preferred.
