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MGUS Predicts Worse Prognosis in Patients with Coronary Artery Disease

Zhao Xu1, Yifeng Sun1, Tianhong Xu1

  • 1Department of Hematology, Zhongshan Hospital Fudan University, 180 Fenglin Road, Shanghai, 200032, China.

Journal of Cardiovascular Translational Research
|January 5, 2020
PubMed

Insights

Patients with monoclonal gammopathy of undetermined significance (MGUS) face a higher risk of major adverse cardiac events (MACE) after coronary artery disease (CAD) diagnosis. MGUS may be a significant factor in CAD risk assessment.

Area of Science:

  • Cardiology
  • Hematology
  • Epidemiology

Background:

  • Coronary artery disease (CAD) is a leading cause of mortality worldwide.
  • Monoclonal gammopathy of undetermined significance (MGUS) is a common plasma cell disorder.
  • The association between MGUS and adverse cardiac outcomes in CAD patients requires further investigation.

Purpose of the Study:

  • To investigate the impact of MGUS on the risk of major adverse cardiac events (MACE) in patients with coronary artery disease (CAD).
  • To identify MGUS as a potential risk factor for adverse cardiac outcomes in CAD patients.

Main Methods:

  • Retrospective cohort study analyzing 87 CAD patients with MGUS and 178 without.
  • Median follow-up of 2.9 years, with MACE as the primary endpoint.
  • Statistical analysis including log-rank tests and stepwise Cox regression, with nomogram construction.

Main Results:

  • CAD patients with MGUS exhibited a significantly higher risk of MACE compared to those without (log-rank P = 0.0015).
  • MGUS remained a significant independent predictor of MACE after adjusting for other risk factors (P = 0.002, HR = 2.308).
  • A predictive nomogram for MACE in CAD patients with MGUS demonstrated a concordance index (C-index) of 0.667.

Conclusions:

  • MGUS is associated with an increased risk of MACE in patients with coronary artery disease.
  • MGUS should be considered as a potential addition to existing risk stratification models for CAD.
  • Further research may elucidate the underlying mechanisms linking MGUS and cardiovascular events.
Keywords:
Coronary artery diseaseMGUSNomogramPrognosis

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