Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Estimation of k and VD of Aminoglycosides

Estimation of k and V_D of Aminoglycosides

Aminoglycosides are a class of antibiotics used to treat various bacterial infections. Clinicians must determine the elimination rate constant (k) and volume of distribution (VD) to optimize therapeutic efficacy and minimize toxicity. The k value represents the rate at which the drug is removed from the body, and the VD reflects the degree to which the drug distributes into body tissues. Accurately estimating these parameters allows healthcare professionals to tailor drug dosing to individual...

Determination of Multiple Dosing Parameters: Loading and Maintenance Doses

Determination of Multiple Dosing Parameters: Loading and Maintenance Doses

A loading dose is an essential pharmacological strategy to rapidly achieve the target plasma drug concentration necessary for an immediate therapeutic effect. This approach is especially critical for drugs characterized by slow absorption or extended half-lives, where delaying therapeutic plasma levels could compromise treatment outcomes. By administering a loading dose, clinicians ensure a prompt onset of drug action, even for agents with complex pharmacokinetic profiles.Achieving steady-state...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Luminescent Polymorphic Co-crystals: A Promising Way to the Diversity of Molecular Assembly, Fluorescence Polarization, and Optical Waveguide.

ACS applied materials & interfaces·2020

Same author

Hyaluronic acid targeted and pH-responsive nanocarriers based on hollow mesoporous silica nanoparticles for chemo-photodynamic combination therapy.

Colloids and surfaces. B, Biointerfaces·2020

Same author

Tumor phase recognition using cone-beam computed tomography projections and external surrogate information.

Medical physics·2020

Same author

Realization of a time-correlated photon counting technique for fluorescence analysis.

Biomedical optics express·2020

Same author

Ultrasonographic Diagnosis of Lipomatosis of Nerve: A Review of Ultrasonographic Finding for 8 Cases.

World neurosurgery·2020

Same author

Is dietary fat associated with the risk of age-related macular degeneration? Protocol for a systematic review and meta-analysis.

Medicine·2020

Same journal

A case study of inhale and exhale split-course VMAT treatment to minimize dose to ribs.

Medical dosimetry : official journal of the American Association of Medical Dosimetrists·2026

Same journal

Prospective clinical implementation of the robust optimization planning technique in long-course photon radiotherapy treatment for lung cancer.

Medical dosimetry : official journal of the American Association of Medical Dosimetrists·2026

Same journal

Dosimetric comparison of target coverage, dose gradient, and low-dose bath in left-sided accelerated partial breast irradiation: CyberKnife versus conventional linac-based noncoplanar VMAT and 3D-CRT.

Medical dosimetry : official journal of the American Association of Medical Dosimetrists·2026

Same journal

Cross-prescription validation of knowledge-based planning in prostate VMAT using a structured validation framework.

Medical dosimetry : official journal of the American Association of Medical Dosimetrists·2026

Same journal

Dosimetric evaluation of beam block techniques in helical tomotherapy for extranodal nasal-type NK/T-cell lymphoma.

Medical dosimetry : official journal of the American Association of Medical Dosimetrists·2026

Same journal

The dosimetric impact to bladder utilizing the Varian Edge linear accelerator for prostate stereotactic body radiation therapy.

Medical dosimetry : official journal of the American Association of Medical Dosimetrists·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Dec 31, 2025

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

A sliding-window approach for improved VMAT dose calculation accuracy.

Haitham N Alahmad¹, Ji-Yeon Park¹, Nicholas J Potter¹

¹Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL 32610-0385, USA.

Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists

|January 6, 2020

Summary

This summary is machine-generated.

A new sliding-window (SW) method improves volumetric modulated arc therapy (VMAT) dose calculation accuracy by approximating VMAT plans with fewer beams. This approach enhances precision without increasing calculation time, as validated in patient studies.

Keywords:

Dose calculation IMRT Treatment plan verification VMAT

More Related Videos

Author Spotlight: A Machine-Vision Approach to Transmission Electron Microscopy Workflows, Results Analysis and Data Management

Author Spotlight: A Machine-Vision Approach to Transmission Electron Microscopy Workflows, Results Analysis and Data Management

Published on: June 23, 2023

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification ADCI and Dose Estimation

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification ADCI and Dose Estimation

Published on: September 4, 2017

Related Experiment Videos

Last Updated: Dec 31, 2025

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

Author Spotlight: A Machine-Vision Approach to Transmission Electron Microscopy Workflows, Results Analysis and Data Management

Author Spotlight: A Machine-Vision Approach to Transmission Electron Microscopy Workflows, Results Analysis and Data Management

Published on: June 23, 2023

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification ADCI and Dose Estimation

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification ADCI and Dose Estimation

Published on: September 4, 2017

Area of Science:

Medical Physics
Radiation Oncology
Radiotherapy Planning

Background:

Volumetric Modulated Arc Therapy (VMAT) dose calculation often uses discrete gantry angles, potentially causing errors with large angle spacings or aperture changes.
Inaccurate dose calculations can arise from approximations in VMAT planning, impacting treatment efficacy.

Purpose of the Study:

To develop and validate a sliding-window (SW) method for improving the accuracy of VMAT dose calculations.
To assess if the SW method can enhance dose accuracy without prolonging treatment planning time.

Main Methods:

A novel sliding-window (SW) method was developed, approximating VMAT plans with fewer SW intensity-modulated radiation therapy (IMRT) beams.
VMAT plans for 10 patients were generated, converted to SW plans, and dose recalculated. Interpolated VMAT plans (1° spacing) and original VMAT plans (4° spacing) were used for comparison.
Original VMAT plans were delivered and measured using an Elekta Versa HD with ArcCHECK for validation.

Main Results:

The SW method and interpolated VMAT plans showed indistinguishable dose distributions and DVHs, unlike the original VMAT plans.
Measurement-based validation revealed that both SW and interpolated VMAT plans achieved higher passing rates (>95%) compared to original VMAT plans (87.3% for HN, 93.1% for spine SBRT).
The dose calculation time for the SW method was comparable to the original VMAT plans.

Conclusions:

The proposed sliding-window (SW) approach significantly improves VMAT dose calculation accuracy.
This enhanced accuracy is achieved without an increase in computational time, making it a viable alternative for radiotherapy planning.
The SW method offers a more precise approximation for continuous VMAT delivery, crucial for complex treatment scenarios.