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Maintenance immunosuppression in myasthenia gravis, an update

John Morren1, Yuebing Li1

  • 1Neuromuscular Center, Neurological Institute, Cleveland Clinic, Cleveland, OH 44195, USA.

Journal of the Neurological Sciences
|January 6, 2020
PubMed

Therapies for myasthenia gravis (MG) include symptomatic and immunosuppressive/immunomodulatory treatment. Options for immunosuppression include corticosteroids, azathioprine, mycophenolate mofetil, cyclosporine, tacrolimus, methotrexate, rituximab, cyclophosphamide, eculizumab, intravenous immunoglobulin, subcutaneous immunoglobulin, plasmapheresis, and thymectomy. The practical aspects of long-term immunosuppressive therapy in MG are critically reviewed in this article. Application of one or more of these specific therapies is guided based on known efficacy, adverse effect profile, particular disease subtype and severity, and patient co-morbidities.

Keywords:
CorticosteroidImmunosuppressionIntravenous immunoglobulinMyasthenia gravisNon-steroid immunosuppressive agentPlasmapheresisThymectomy

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