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Progressive effects of single-nucleotide polymorphisms on 16 phenotypic traits based on longitudinal data
Donghe Li1, Hahn Kang2, Sanghun Lee3
1Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, Republic of Korea.
Genes & Genomics
|January 6, 2020
Summary
This study found significant genetic influences on longitudinal changes in forced vital capacity in one second (FEV1) in middle-aged adults. Chromosome 2 plays a key role in the genetic variance of these changes.
Area of Science:
- Genetics
- Pulmonology
- Biostatistics
Background:
- Heritability of phenotypic traits is widely studied, but few studies examine longitudinal changes in multiple traits together.
- Longitudinal data analysis is crucial for understanding dynamic changes in health-related traits.
Purpose of the Study:
- To assess the progressive impact of single nucleotide polymorphisms (SNPs) on key health-related phenotypic traits.
- To determine SNP-based heritability using longitudinal data from a large cohort.
Main Methods:
- Utilized data from 6843 individuals in a Korean community-based cohort with a 10-year follow-up.
- Estimated average SNP heritability and longitudinal changes using a two-stage model and genome-wide association study (GWAS).
Main Results:
- All sixteen phenotypic traits showed significant SNP heritability at baseline.
- Forced vital capacity in one second (FEV1) was the only trait with significant SNP heritability in longitudinal changes.
- Chromosome 2 showed the highest heritability for periodic changes in FEV1, with specific SNPs associated with these changes.
Conclusions:
- Genetic factors significantly influence longitudinal changes in FEV1 in the middle-aged general population.
- Chromosome 2 is a major contributor to the genetic variance observed in FEV1 longitudinal changes.
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