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Related Experiment Video

Updated: Dec 31, 2025

A Model for Encephalomyosynangiosis Treatment after Middle Cerebral Artery Occlusion-Induced Stroke in Mice
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Osteocalcin improves outcome after acute ischemic stroke.

Jiayan Wu1, Yunxiao Dou1, Wangmi Liu2

  • 1Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200032, China.

Aging
|January 7, 2020
PubMed
Summary
This summary is machine-generated.

Osteocalcin may improve outcomes in acute ischemic stroke patients. This bone-derived hormone promotes neuron survival by regulating metabolism and inhibiting cell death pathways, offering a potential therapeutic target.

Keywords:
NIHSS scoreacute ischemic strokeosteocalcinproline hydroxylase 1pyroptosis

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Area of Science:

  • Neuroscience
  • Metabolic research
  • Bone biology

Background:

  • Osteocalcin links bone health to brain functions like energy metabolism and stress response.
  • A direct role for osteocalcin in acute ischemic stroke outcomes requires urgent investigation.

Purpose of the Study:

  • To investigate the effect of osteocalcin on acute ischemic stroke outcomes.
  • To elucidate the underlying mechanisms of osteocalcin's action in cerebral ischemia.

Main Methods:

  • Analysis of demographic and laboratory data from acute ischemic stroke patients.
  • Utilizing receiver operating characteristic curve analysis for prediction model assessment.
  • In vitro experiments on cultured rat neurons subjected to oxygen-glucose deprivation and reoxygenation to explore osteocalcin's mechanism.

Main Results:

  • Higher serum osteocalcin levels correlated with better patient outcomes and improved NIHSS scores.
  • Osteocalcin demonstrated a neuroprotective effect, promoting neuron survival in vitro.
  • Osteocalcin was found to downregulate proline hydroxylase 1 and inhibit gasdermin D degradation.

Conclusions:

  • Osteocalcin shows potential for improving outcomes during the acute phase of ischemic stroke.
  • The mechanism involves downregulating proline hydroxylase 1, shunting glucose metabolism to the pentose phosphate pathway, and inhibiting pyroptosis to enhance neuronal survival.