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The Emerging Link between the Hippo Pathway and Non-coding RNA.

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The Hippo pathway regulates cell fate. This review explores how non-coding RNAs like microRNAs interact with the Hippo pathway to control biological processes and maintain cell balance.

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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Genetics

Background:

  • The Hippo signaling pathway is crucial for cell fate determination.
  • While key Hippo pathway components are known, its complete network is still being uncovered.
  • Non-coding RNAs (ncRNAs) are increasingly recognized for their regulatory roles in cellular processes.

Purpose of the Study:

  • To review the interplay between the Hippo pathway and non-coding RNAs.
  • To summarize current and emerging knowledge on ncRNA regulation by and of the Hippo pathway.
  • To highlight the role of ncRNAs in mediating biological processes within the Hippo network.

Main Methods:

  • Literature review of recent discoveries in the past decade.
  • Analysis of studies investigating Hippo pathway components.
  • Synthesis of research on microRNAs, long non-coding RNAs, and circular RNAs in relation to the Hippo pathway.

Main Results:

  • The Hippo pathway interacts with various non-coding RNAs (microRNAs, lncRNAs, circRNAs).
  • These non-coding RNAs form complex networks that communicate with each other.
  • This intricate network plays a role in maintaining cellular homeostasis and mediating diverse biological functions.

Conclusions:

  • Non-coding RNAs are integral regulators of the Hippo signaling pathway.
  • The Hippo pathway and non-coding RNAs form a sophisticated network essential for cellular regulation.
  • Further research into this crosstalk will illuminate fundamental biological mechanisms.