Relationship between optical perfusion pressure and systemic blood pressure on glaucoma: Case-control study

Area of Science:

• Ophthalmology
• Cardiovascular Science

Background:

• Open-angle glaucoma (OAG) is a leading cause of irreversible blindness worldwide.
• Intraocular pressure (IOP) and blood pressure (BP) are known risk factors, but their interplay with ocular perfusion pressure (OPP) in POAG requires further investigation.

Purpose of the Study:

• To examine the relationship between blood pressure (BP), ocular perfusion pressure (OPP), intraocular pressure (IOP), and primary open-angle glaucoma (POAG).
• To identify potential risk factors for POAG among hemodynamic parameters.

Main Methods:

• A hospital-based, case-control cross-sectional study involving 150 participants (75 POAG patients, 75 controls).
• Diagnosis of POAG confirmed via disc evaluation, gonioscopy, perimetry, and applanation tonometry.
• Calculation of Mean Ocular Perfusion Pressure (MOPP), Systolic Perfusion Pressure (SPP), and Diastolic Perfusion Pressure (DPP) based on measured BP and IOP.

Main Results:

• Diastolic blood pressure (DBP), OPP, SPP, and DPP showed a positive association with POAG.
• Lower OPP (<50 mmHg) was strongly associated with increased POAG risk (OR=0.075).
• Lower DPP (<55 mmHg) was also linked to increased POAG risk (OR=0.020).

Conclusions:

• Low mean ocular perfusion pressure (MOPP) and low diastolic perfusion pressure (DPP) are significantly associated with a higher prevalence of POAG.
• These low perfusion pressures are identified as independent risk factors for open-angle glaucoma (OAG).