Treatment Outcome Prediction for Cancer Patients based on Radiomics and Belief Function Theory

In this study, we proposed a new radiomics-based treatment outcome prediction model for cancer patients. The prediction model is developed based on belief function theory (BFT) and sparsity learning to address the challenges of redundancy, heterogeneity, and uncertainty of radiomic features, and relatively small-sized and unbalanced training samples. The model first selects the most predictive feature subsets from relatively large amounts of radiomic features extracted from pre- and/or in-treatment positron emission tomography (PET) images and available clinical and demographic features. Then an evidential k-nearest neighbor (EK-NN) classifier is proposed to utilize the selected features for treatment outcome prediction. Twenty-five stage II-III lung, 36 esophagus, 63 stage II-III cervix, and 45 lymphoma cancer patient cases were included in this retrospective study. Performance and robustness of the proposed model were assessed with measures of feature selection stability, outcome prediction accuracy, and receiver operating characteristics (ROC) analysis. Comparison with other methods were conducted to demonstrate the feasibility and superior performance of the proposed model.