Related Experiment Video
Updated: Dec 31, 2025

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
Peri-operative cardiac biomarker screening: a narrative review
S M Ruzycki1, M Prystajecky2, M R Driedger3
1Department of Medicine, Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, AB, Canada.
Insights
Cardiac biomarker testing offers superior peri-operative risk assessment compared to traditional functional tests. This approach improves prediction of patient outcomes and guides management strategies.
Area of Science:
- Cardiology
- Peri-operative Medicine
- Risk Stratification
Background:
- Traditional peri-operative risk estimation relies on pre-operative functional assessment.
- Current guidelines recommend functional assessment for predicting postoperative complications.
- Emerging evidence highlights limitations of functional assessment alone.
Purpose of the Study:
- To review evidence supporting cardiac biomarker use in peri-operative risk estimation.
- To compare cardiac biomarkers with traditional functional assessment methods.
- To identify patient groups benefiting from cardiac biomarker screening and discuss management protocols.
Main Methods:
- Systematic review of contemporary evidence on cardiac biomarker utility.
- Comparative analysis of predictive accuracy between biomarker and functional assessments.
- Discussion of clinical protocols for screening and management.
Main Results:
- Cardiac biomarker measurement demonstrates superior predictive discrimination for peri-operative events.
- Biomarker assessment incorporates the postoperative course, offering a more comprehensive risk profile.
- Evidence supports expanded use of biomarkers in specific patient populations.
Conclusions:
- Cardiac biomarkers represent a significant advancement over traditional functional assessments for peri-operative risk stratification.
- Implementation of biomarker screening protocols can optimize patient management and improve outcomes.
- Further research should focus on refining screening criteria and management strategies.
Abstract:
Peri-operative risk estimation has traditionally focused on assessing the likelihood of postoperative morbidity and mortality using pre-operative functional assessment. Although this strategy is currently recommended by most major society guidelines, contemporary evidence suggests that cardiac biomarker measurement has important advantages over pre-operative functional assessment. These advantages include superior predictive discrimination and inclusion of the postoperative course in risk estimation. In this review, we provide an overview of the evidence supporting the peri-operative utilisation, compare risk estimation methods and discuss which patients may benefit most from cardiac biomarker screening. We also discuss protocols for biomarker screening and management of patients with abnormal results.
Related Concept Videos
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Cardiac Catheterization I: Pre-Procedure Overview
Cardiomyopathy VII: Pre and Post Operative Nursing Management
Blood Studies for Cardiovascular System I: Cardiac Biomarkers
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
Cardiac Catheterization IV: Nursing Management
Acute Coronary Syndrome III: Diagnostic Studies

