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Updated: Dec 31, 2025
Using 22C3 Anti-PD-L1 Antibody Concentrate on Biopsy and Cytology Samples from Non-small Cell Lung Cancer Patients
Published on: September 25, 2018
Adrenal diffuse large B-cell lymphoma with high PD-L1 expression: Two case reports and literature review
Yu Chen1, He Sheng He2, Qing Feng Hu1
1Department of Hematology, The Second affiliated Hospital of Wannan Medical College, Wuhu, China.
Background:
Primary adrenal lymphoma (PAL) is an infrequent malignant disease and there is no consensus classification or specialized treatment for it. However, PAL has been observed to have worse prognosis compared with other extrarenal malignant lymphomas and diffuse large B-cell lymphoma presents as the most common subtype of PAL.
Methods:
The current study reported two cases of adrenal diffuse large B-cell lymphoma with high PD-L1 expression and discussed the clinical significance of PD-L1 through literature review.
Key Results:
The PD-L1 expression rate of the two cases was 90% and 80%, respectively, which was significantly higher than those reported in the literature.
Conclusion:
PAL is a type of non-Hodgkin's lymphoma with low incidence and poor prognosis, and it is necessary to further explore the early use of immunological checkpoint inhibitors for patients with higher expression of PD-L1 and with rituximab-resistance.
