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MASS SPECTROMETRY-BASED PERSONALIZED DRUG THERAPY.

Jia-Jia Cui1,2,3,4, Lei-Yun Wang1,2,3,4, Zhi-Rong Tan1,2,3,4

  • 1Department of Clinical Pharmacology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, P. R. China.

Mass Spectrometry Reviews
|January 7, 2020
PubMed
Summary

Mass spectrometry (MS) advances personalized drug therapy through five key areas: therapeutic drug monitoring, pharmacogenomics, pharmacomicrobiomics, pharmacoepigenomics, and immunopeptidomics, enhancing treatment tailoring.

Keywords:
cancer immunotherapyimmunopeptidomicsmass spectrometrypersonalized drug therapypharmacoepigenomicspharmacogenomics (PGx)pharmacomicrobiomicsprecision medicinetherapeutic drug monitoring (TDM)

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Area of Science:

  • Analytical Chemistry
  • Pharmacology
  • Biotechnology

Background:

  • Personalized drug therapy tailors treatments to individual patients.
  • Mass spectrometry (MS) offers a rapid, sensitive, and accurate high-throughput method for this field.
  • MS is foundational to the emerging area of MS-based personalized drug therapy.

Purpose of the Study:

  • To systematically review the five subfields of MS-based personalized drug therapy.
  • To highlight the role of MS technologies in advancing tailored medical treatments.
  • To provide an overview of current applications and future potential.

Main Methods:

  • Review of scientific literature on MS applications in personalized medicine.
  • Focus on techniques like Gas Chromatography-MS (GC-MS), Liquid Chromatography-MS (LC-MS), and Matrix-Assisted Laser Desorption Ionization-Time of Flight-MS (MALDI-TOF-MS).
  • Exploration of MS in therapeutic drug monitoring, pharmacogenomics, pharmacomicrobiomics, pharmacoepigenomics, and immunopeptidomics.

Main Results:

  • GC-MS and LC-MS are gold standards for therapeutic drug monitoring (TDM) to optimize drug dosage.
  • MALDI-TOF-MS is crucial for genotyping in pharmacogenomics (PGx) and identifying microbiome variations affecting drug response.
  • MS facilitates discovery and validation of epigenetic markers and neoantigens for personalized treatments.

Conclusions:

  • Mass spectrometry is indispensable for personalized drug therapy, spanning multiple critical subfields.
  • MS technologies enable precise drug dosage optimization, genetic and epigenetic marker identification, and personalized vaccine development.
  • The integration of MS drives innovation in tailoring medical treatments for individual patients.