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Curcumin-loaded polysaccharides-based complex particles obtained by polyelectrolyte complexation and ionic gelation.

Camelia-Elena Iurciuc-Tincu1, Leonard Ionuţ Atanase2, Lăcrămioara Ochiuz3

  • 1"Grigore T. Popa" University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Technology, University street, no. 16, 700115 Iaşi, Romania; "Gheorghe Asachi" Technical University, Faculty of Chemical Engineering and Protection of the Environment, Department of Natural and Synthetic Polymers, Iaşi, Romania.

International Journal of Biological Macromolecules
|January 7, 2020
PubMed
Summary

New polysaccharide microparticles effectively immobilize curcumin, enhancing its stability and bioavailability for potential oral drug delivery. These particles protect curcumin from degradation, targeting colon-specific release.

Keywords:
Curcumin immobilizationIonic cross-linkingPolyelectrolyte complexationPolysaccharides microparticles

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Area of Science:

  • Materials Science
  • Pharmaceutical Sciences
  • Biotechnology

Background:

  • Curcumin exhibits significant therapeutic potential but suffers from poor water solubility and low bioavailability.
  • Developing effective delivery systems is crucial to harness curcumin's medicinal properties.

Purpose of the Study:

  • To immobilize curcumin into novel polysaccharide-based microparticles (gellan, i-carrageenan, chitosan) to improve its stability and bioavailability.
  • To investigate the characteristics and curcumin release kinetics of these microparticle systems.

Main Methods:

  • Curcumin was loaded into polysaccharide microparticles using ionic cross-linking and polyelectrolyte complexation.
  • Microparticle morphology was analyzed using Scanning Electron Microscopy (SEM).
  • Swelling behavior, FT-IR spectroscopy, and curcumin release kinetics at different pH values were evaluated.

Main Results:

  • High curcumin immobilization efficiency (85.75%–97.25%) was achieved.
  • i-carrageenan containing microparticles showed enhanced matrix porosity.
  • Microparticles demonstrated pH-dependent swelling and controlled curcumin release, with higher efficiency at pH 7.4.

Conclusions:

  • Polysaccharide-based microparticles offer a promising strategy for enhancing curcumin stability and bioavailability.
  • These microparticles are suitable for oral administration, enabling colon-targeted, controlled release of curcumin while protecting it from gastric degradation.