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Collagen stabilization using ionic liquid functionalised cerium oxide nanoparticle.

Chandrasekar Inbasekar1, Nishter Nishad Fathima1

  • 1Inorganic and Physical Chemistry Laboratory, CSIR-Central Leather Research Institute, Adyar, Chennai 600020, India.

International Journal of Biological Macromolecules
|January 7, 2020
PubMed
Summary

Ionic liquid-functionalized cerium oxide nanoparticles (IL-CONP) effectively stabilize collagen. These nanoparticles enhance collagen

Keywords:
Cerium oxide nanoparticlesCollagenConformational stabilityCrosslinking agentThermal stability

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Area of Science:

  • Materials Science
  • Biotechnology
  • Nanotechnology

Background:

  • Nanoparticles significantly influence collagen's biological behavior.
  • Collagen stabilization is crucial for various biomedical applications.
  • Cerium oxide nanoparticles act as biocatalysts due to their variable oxidation states.

Purpose of the Study:

  • To synthesize and characterize ionic liquid-functionalized cerium oxide nanoparticles (IL-CONP).
  • To investigate the crosslinking efficiency and collagen stabilization capabilities of IL-CONP.

Main Methods:

  • Synthesis of IL-CONP via sonication.
  • Characterization using Dynamic Light Scattering (DLS) and X-ray Diffraction (XRD).
  • Assessment of collagen structural changes and thermal stability using Differential Scanning Calorimetry (DSC).

Main Results:

  • IL-CONP characterized with a hydrodynamic diameter of 192.3 ± 2.14 nm, Zeta potential of -13.76 ± 1.5 mV, and PDI of 0.387.
  • Conformational modifications in collagen's secondary structure observed with increasing IL-CONP concentration.
  • Significant increase in collagen thermal stability from 61°C to 87°C upon IL-CONP treatment.

Conclusions:

  • IL-CONP demonstrate effective crosslinking and stabilization of collagen.
  • Cerium oxide-based nanoparticles show promise as crosslinking agents for collagen.
  • The findings open new avenues for nanoparticle applications in collagen modification.