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Exosomes in triple negative breast cancer: Garbage disposals or Trojan horses?

Chia Yin Goh1, Cathy Wyse1, Matthew Ho1

  • 1UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield Dublin, Dublin 4, Ireland; UCD School of Medicine, College of Health and Agricultural Sciences (CHAS), University College Dublin, Belfield Dublin, Dublin 4, Ireland.

Cancer Letters
|January 7, 2020
PubMed

Insights

Triple negative breast cancer (TNBC) is aggressive, lacking treatment targets. Exosomes, tiny vesicles carrying cell information, show promise for TNBC diagnosis, therapy, and drug delivery, offering new avenues for this challenging cancer.

Area of Science:

  • Oncology
  • Cell Biology
  • Nanotechnology

Background:

  • Triple negative breast cancer (TNBC) is an aggressive subtype with limited therapeutic options due to a lack of specific molecular targets.
  • Exosomes, nanoscale extracellular vesicles, are increasingly recognized for their roles in intercellular communication and disease pathology, including cancer.

Purpose of the Study:

  • To review the multifaceted roles of exosomes in the progression, metastasis, and drug resistance of triple negative breast cancer.
  • To explore the potential applications of exosomes as diagnostic biomarkers, therapeutic targets, and drug delivery systems for TNBC.

Main Methods:

  • Literature review focusing on studies investigating exosome involvement in TNBC.
  • Analysis of exosome content and function in the context of cancer biology.

Main Results:

  • Exosomes contribute to TNBC progression, facilitate metastasis, and mediate drug resistance.
  • Exosomes contain molecular cargo that can serve as potential biomarkers for TNBC diagnosis.

Conclusions:

  • Exosomes represent a promising area of research for understanding and treating triple negative breast cancer.
  • Harnessing exosomes offers potential for novel diagnostic tools, targeted therapies, and advanced drug delivery systems for TNBC.

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