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Circumferential canal surgery: a brief history.
Jaime E Dickerson1,2, Reay H Brown1,3
1Sight Sciences Inc., Menlo Park, California.
Current Opinion in Ophthalmology
|January 7, 2020
Summary
A new microinvasive glaucoma surgery (MIGS) approach combines trabeculotomy with viscodilation to address both proximal and distal outflow resistance. This novel procedure shows significant intraocular pressure reduction, offering a promising MIGS modality.
Area of Science:
- Ophthalmology
- Glaucoma Surgery
- Surgical Innovation
Background:
- Current microinvasive glaucoma surgery (MIGS) primarily targets proximal outflow resistance in the trabecular meshwork and Schlemm's canal.
- Addressing distal resistance in Schlemm's canal and collector channels remains a challenge for existing MIGS procedures.
Observation:
- Recent aqueous angiography confirms segmental outflow through Schlemm's canal, emphasizing the need to treat distal resistance.
- A novel ab interno procedure combines trabeculotomy with viscodilation, utilizing a new device (OMNI Surgical System) available since early 2018.
Findings:
- This combined approach demonstrated significant intraocular pressure reduction, averaging a 41% decrease from baseline in pseudophakic patients.
- Results were observed when the procedure was performed as a standalone treatment or in conjunction with cataract surgery.
Implications:
- Targeting both proximal and distal outflow resistance may represent a highly effective MIGS strategy.
- Further large-scale prospective studies are underway to validate these promising preliminary findings.

