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Related Experiment Videos

Pulmonary function and dysfunction in multiple sclerosis.

S C Smeltzer1, M J Utell, R A Rudick

  • 1Rutgers--the State University of New Jersey, College of Nursing, Newark 07102.

Archives of Neurology
|November 1, 1988
PubMed
Summary
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Multiple sclerosis patients with severe motor impairment experience reduced pulmonary function, particularly expiratory muscle weakness. This weakness worsens with increased upper extremity involvement and disability progression.

Area of Science:

  • Neurology
  • Pulmonology
  • Rehabilitation Medicine

Background:

  • Multiple sclerosis (MS) is a chronic demyelinating disease affecting the central nervous system.
  • Motor impairment is a common symptom of MS, impacting various bodily functions.
  • Pulmonary complications can arise from neuromuscular deficits in MS.

Purpose of the Study:

  • To investigate pulmonary function in patients with multiple sclerosis.
  • To assess the relationship between motor impairment severity and respiratory muscle strength.
  • To identify specific patterns of pulmonary dysfunction in relation to MS disability.

Main Methods:

  • Studied 25 patients with clinically definite multiple sclerosis.
  • Assessed pulmonary function including Forced Vital Capacity (FVC), Maximal Voluntary Ventilation (MVV), and Maximal Expiratory Pressure (MEP).

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  • Correlated pulmonary function measures with Kurtzke Expanded Disability Status scores and degree of motor impairment.

    • Main Results:

    • Ambulatory MS patients showed normal pulmonary function (>= 80% predicted).
    • Bedridden and wheelchair-bound MS patients with upper extremity involvement exhibited significantly reduced FVC, MVV, and MEP.
    • Pulmonary function parameters correlated negatively with Kurtzke Expanded Disability Status scores (tau = -0.72 to -0.65).
    • Expiratory muscle weakness was the most frequent finding, particularly in severely impaired patients.

    Conclusions:

    • Severe motor impairment in multiple sclerosis leads to significant expiratory muscle weakness.
    • Pulmonary function deficits, especially expiratory weakness, increase with greater disability and upper extremity involvement in MS patients.
    • Regular pulmonary function assessment is crucial for managing MS patients with progressive motor deficits.