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Collagen degradation by experimentally-induced subcutaneous granulation tissue in the rat
1Department of Periodontology, Karolinska Institute, Huddinge University Hospital, Sweden.
Archives of Oral Biology
|January 1, 1988
Abstract:
Granulation tissue provoked by implantation of cellulose sponge or a nylon bag degraded a powder of homologous collagen. This activity was located in a non-filtrable tissue fraction and was associated with the appearance of mononuclear and histiocytic giant cells, following an early polymorphonuclear-cell infiltration. The activity could be manipulated experimentally, indicating that this model can be used in investigations of inflammation-induced collagen degradation.