Cerebral Microbleeds in a Stroke Prevention Clinic

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A-Hyun Cho1,2, Lara Wadi1, Daniel Chow3

  • 1Department of Neurology, University of California, Irvine, Orange, CA 92868, USA.

Diagnostics (Basel, Switzerland)
|January 8, 2020
PubMed

Insights

A stroke clinic study found cerebral microbleeds (CMB) progression in 54% of patients. Higher intracranial calcification correlated with greater CMB burden, suggesting a link for further research.

Area of Science:

  • Neurology
  • Radiology
  • Vascular Medicine

Background:

  • Cerebral microbleeds (CMB) are associated with stroke risk.
  • Understanding CMB progression and its relationship with intracranial calcification is crucial for stroke prevention.

Purpose of the Study:

  • To evaluate the effectiveness of a stroke clinic in preventing strokes and managing cerebral microbleeds (CMB).
  • To assess the progression of CMB and its association with intracranial calcification.

Main Methods:

  • Retrospective observational study of 64 stroke patients with CMB from January 2011 to March 2017.
  • Susceptibility-weighted imaging (SWI) MRI used for CMB and new infarction detection; CT imaging for intracranial calcification quantification.
  • Analysis of stroke incidence, CMB progression, and correlation between calcification burden and CMB count.

Main Results:

  • Four strokes (6%) occurred during a mean 22.6-month follow-up, with mild deficits.
  • CMB progression observed in 54% of patients and linked to follow-up duration.
  • Patients with intracranial calcification scores >300 cm³ had significantly higher CMB counts at baseline and follow-up compared to those with scores <300 cm³.

Conclusions:

  • Stroke clinic patients with CMB experienced a relatively benign clinical course.
  • A significant association exists between intracranial calcification burden and CMB load.
  • Further investigation into the relationship between CMB and intracranial calcification is warranted.
Keywords:
CTMRIcerebral microbleedscerebrovascular disease/strokeinfarctionstroke prevention

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