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Updated: Dec 31, 2025

Spatiotemporal Analysis of Cytokinetic Events in Fission Yeast
Published on: February 20, 2017
PP2A Functions during Mitosis and Cytokinesis in Yeasts
Yolanda Moyano-Rodriguez1, Ethel Queralt1
1Cell Cycle Group, Institut d'Investigació Biomèdica de Bellvitge-IDIBELL, Av. Gran Via de L'Hospitalet 199-203, L'Hospitalet de Llobregat, E-08908 Barcelona, Spain.
Abstract:
Protein phosphorylation is a common mechanism for the regulation of cell cycle progression. The opposing functions of cell cycle kinases and phosphatases are crucial for accurate chromosome segregation and exit from mitosis. Protein phosphatases 2A are heterotrimeric complexes that play essential roles in cell growth, proliferation, and regulation of the cell cycle. Here, we review the function of the protein phosphatase 2A family as the counteracting force for the mitotic kinases. We focus on recent findings in the regulation of mitotic exit and cytokinesis by PP2A phosphatases in S. cerevisiae and other fungal species.
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