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Lipid Systems for the Delivery of Amphotericin B in Antifungal Therapy

Célia Faustino1, Lídia Pinheiro1

  • 1Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal.

Pharmaceutics
|January 8, 2020
PubMed

Insights

Researchers are developing novel lipid-based delivery systems for Amphotericin B (AmB) to improve its effectiveness and reduce side effects. These advanced formulations aim for better drug accessibility, potentially through oral administration, offering a breakthrough in treating serious fungal infections.

Area of Science:

  • Pharmacology
  • Drug Delivery Systems
  • Nanotechnology

Background:

  • Amphotericin B (AmB) is a critical antifungal and antileishmanial drug but faces limitations due to poor solubility and toxicity.
  • Conventional formulations cause severe side effects and nephrotoxicity, while liposomal versions are costly and require injection.
  • There is a significant need for safer, more accessible Amphotericin B formulations.

Purpose of the Study:

  • To review recent advancements in lipid-based delivery systems for Amphotericin B.
  • To focus on non-parenteral, nanoparticulate formulations developed in the last five years.
  • To highlight promising lipid systems currently in clinical trials.

Main Methods:

  • Literature review of recent scientific publications and clinical trial data.
  • Focus on lipid-based nanoparticulate systems for Amphotericin B delivery.
  • Analysis of formulations targeting improved efficacy and reduced toxicity.

Main Results:

  • Lipid systems show high affinity for Amphotericin B, enabling targeted delivery.
  • Non-parenteral formulations, particularly nanoparticulate ones, are under active investigation.
  • Several novel lipid-based systems are progressing towards or are in clinical trials.

Conclusions:

  • Lipid-based systems offer a promising strategy to overcome Amphotericin B's limitations.
  • Development of safe, cost-effective oral formulations is a key goal.
  • Continued research in this area could lead to improved treatment options for invasive fungal infections and leishmaniasis.
Keywords:
amphotericin Bdrug deliveryfungal diseasesinfectionlipid systemsnanoparticles

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