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Author Spotlight: Investigating the Motion Dynamics of the Eukaryotic Replisome Components at the Single-Molecule Level
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Unwinding 20 Years of the Archaeal Minichromosome Maintenance Helicase
Lori M Kelman1, William B O'Dell2,3, Zvi Kelman4,3
1Program in Biotechnology, Montgomery College, Germantown, Maryland, USA.
Abstract:
Replicative DNA helicases are essential cellular enzymes that unwind duplex DNA in front of the replication fork during chromosomal DNA replication. Replicative helicases were discovered, beginning in the 1970s, in bacteria, bacteriophages, viruses, and eukarya, and, in the mid-1990s, in archaea. This year marks the 20th anniversary of the first report on the archaeal replicative helicase, the minichromosome maintenance (MCM) protein. This minireview summarizes 2 decades of work on the archaeal MCM.
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