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The Neuroimmune Axis in the Tumor Microenvironment
Michael R Shurin1,2, Galina V Shurin3, Samuel B Zlotnikov3
1Department of Pathology, University of Pittsburgh Medical Center and University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232; shurinmr@upmc.edu.
Journal of Immunology (Baltimore, Md. : 1950)
|January 8, 2020
Summary
Peripheral nerves influence cancer progression and metastasis. Schwann cells, a type of glial cell, accelerate tumor cell migration and metastasis, highlighting neuroimmune circuits
Area of Science:
- Oncology
- Neuroscience
- Immunology
Background:
- Cancer is a complex ecosystem influenced by its microenvironment, including nerves.
- Neuroimmune cross-talk is increasingly recognized as crucial in cancer progression.
- The specific role of neuroglial cells in cancer remains underexplored.
Purpose of the Study:
- To investigate the immunomodulatory role of neuroglial cells in cancer progression and metastasis.
- To understand how Schwann cells impact malignant cell behavior and therapy response.
- To elucidate neuroimmune circuits within the tumor microenvironment.
Main Methods:
- Analysis of the tumor microenvironment.
- Investigation of neuroglial cell interactions with cancer cells.
- Studies on the effects of Schwann cells on tumor growth and metastasis.
Main Results:
- Peripheral nerves modulate cancer cell phenotype, growth, and metastasis.
- Schwann cells, a type of glial cell, are key players in the tumor microenvironment.
- Schwann cells can directly accelerate malignant cell migration and metastasis formation.
Conclusions:
- Understanding neuroimmune circuits is vital for developing novel cancer therapies.
- Targeting neuroglial cells may offer new therapeutic strategies for inflammation-associated malignancies.
- Further research into neuroimmune interactions in cancer is warranted.
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