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Updated: Dec 31, 2025

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Dynamic responses of the haematopoietic stem cell niche to diverse stresses

Antoniana Batsivari1, Myriam Luydmila Rachelle Haltalli2,3, Diana Passaro1

  • 1Haematopoietic Stem Cell Laboratory, The Francis Crick Institute , London, UK.

Nature Cell Biology
|January 8, 2020
PubMed

Adult haematopoietic stem cells (HSCs) mainly reside in the bone marrow, where stromal and haematopoietic cells regulate their function. The steady state HSC niche has been extensively studied. In this Review, we focus on how bone marrow microenvironment components respond to different insults including inflammation, malignant haematopoiesis and chemotherapy. We highlight common and unique patterns among multiple cell types and their environment and discuss current limitations in our understanding of this complex and dynamic tissue.

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