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Related Concept Videos

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Related Experiment Video

Updated: Dec 31, 2025

Electrocardiogram Recordings in Anesthetized Mice using Lead II
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Does infection prolong the QT interval?

Frieda Wolf1, Mohammad Homiedi2, Mazen Elias1

  • 1Internal Medicine C, Emek Medical Center, Afula, Iran.

Internal Medicine Journal
|January 8, 2020
PubMed
Summary
This summary is machine-generated.

Hospitalization for infection does not appear to prolong the corrected QT (QTc) interval, a key indicator of heart disease risk. This study found no significant association between infections and QTc prolongation.

Keywords:
QTc intervalantibioticshospitalisationinfection

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Area of Science:

  • Cardiology
  • Infectious Diseases
  • Electrocardiography

Background:

  • The corrected QT (QTc) interval is a critical predictor of ischemic heart disease, cardiovascular mortality, lethal arrhythmias, and sudden death.
  • Previous research indicated QTc prolongation in pneumonia patients, but it was unclear if this was due to pneumonia itself or other infections.
  • Risk factors for QTc prolongation include electrolyte imbalances, medications, cardiovascular disease, and genetic factors.

Purpose of the Study:

  • To determine if hospitalization for any infection is associated with QTc interval prolongation.
  • To differentiate between QTc prolongation caused by specific infections versus general hospitalization for infection.

Main Methods:

  • 160 patients hospitalized for infection were analyzed.
  • Corrected QT (QTc) intervals were measured via routine electrocardiogram (ECG) upon admission and daily for up to three days or until discharge.
  • Investigations for potential causes were conducted if clinically significant QTc prolongation was detected.

Main Results:

  • No clinically significant QTc prolongation was observed in any patient.
  • A slight, non-significant increase in QTc was noted on admission for pneumonia or upper respiratory tract infections.
  • Factors like male sex, ischemic heart disease, hypertension, cerebrovascular accident history, and cancer were associated with a slightly longer QTc, but not with subsequent prolongation.
  • No association was found between systemic inflammatory response syndrome (SIRS) scores and QTc interval changes.

Conclusions:

  • Hospitalization for infection is not associated with QTc interval prolongation.
  • The study did not find evidence to support a link between general infections and potentially dangerous heart rhythm changes.