Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

CNS Stimulants: Cocaine, Amphetamines and Cannabinoids01:24

CNS Stimulants: Cocaine, Amphetamines and Cannabinoids

697
CNS stimulants, such as cocaine, amphetamines, and cannabinoids, have varying structures and mechanisms of action that lead to different therapeutic effects and side effects. Cocaine, with its molecular formula C17H21NO4, is a tropane alkaloid and a tertiary amino compound. It has two chemical forms: the hydrochloride salt and the "freebase." The former is in powder form, while the latter involves removing the hydrochloride salt to create a form that can be smoked. Cocaine exerts its...
697
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids01:21

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids

627
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
627
Drug Abuse and Addiction: Pharmacological Phenomena01:15

Drug Abuse and Addiction: Pharmacological Phenomena

1.0K
Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
1.0K
Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

677
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
677
Hallucinogens and Psychedelics01:27

Hallucinogens and Psychedelics

529
Hallucinogens are psychoactive substances that profoundly alter perceptual experiences, generating unreal visual and sensory images. Often referred to as psychedelic drugs — a term derived from the Greek words "psyche" (mind) and "delos" (revealing) — these substances include marijuana and lysergic acid diethylamide (LSD), among others. These drugs vary in intensity and effects.
Marijuana, derived from the dried leaves and flowers of the hemp plant, contains...
529
Human Genetics01:28

Human Genetics

1.3K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Kv7.2 loss-of-function causes early hyperexcitability and network remodelling.

Brain : a journal of neurology·2026
Same author

Beyond seizures: proceedings of the ERN EpiCARE working group 18 on developmental and epileptic encephalopathies.

Epilepsy & behavior : E&B·2026
Same author

Management of ring chromosome 20 syndrome: Narrative review and consensus recommendations.

Epilepsia·2026
Same author

Evolution of the European Medicines Agency clinical guidelines for epilepsy drug development between 2010 and 2025: A comparative analysis by the ILAE Task Force on Regulatory Affairs.

Epilepsia·2026
Same author

Transcription Factor Binding and Individual Genetic Risk of Valproate Teratogenicity.

Neurology·2026
Same author

Unilateral eye occlusion (patching) in Sunflower syndrome: Promise, limitations, and future directions.

Developmental medicine and child neurology·2026

Related Experiment Video

Updated: Dec 31, 2025

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
07:51

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice

Published on: August 1, 2025

732

Long-term effects of cannabinoids on development/behaviour.

Lieven Lagae1

  • 1Paediatric Neurology, UZ Leuven, Member of the European Reference Network EpiCARE, Leuven, Belgium.

Epileptic Disorders : International Epilepsy Journal with Videotape
|January 8, 2020
PubMed
Summary
This summary is machine-generated.

Cannabis-derived products like cannabidiol may pose risks to children with epilepsy. Long-term use could negatively impact cognitive and behavioral functions, requiring further research.

Keywords:
EpidiolexEpidyolexbehaviourcannabidiolcannabisdevelopmentlong-term effects

More Related Videos

Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes
05:13

Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes

Published on: February 28, 2025

551
Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
07:30

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

7.4K

Related Experiment Videos

Last Updated: Dec 31, 2025

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
07:51

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice

Published on: August 1, 2025

732
Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes
05:13

Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes

Published on: February 28, 2025

551
Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
07:30

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

7.4K

Area of Science:

  • Pediatric Neurology
  • Pharmacology
  • Child Psychology

Background:

  • Cannabis-derived products, including cannabidiol, are increasingly used for refractory childhood epilepsy.
  • Concerns exist regarding the cognitive and behavioral safety of chronic use in young children.
  • Limited long-term data necessitates indirect evidence for safety assessment.

Purpose of the Study:

  • To review indirect evidence on the cognitive and behavioral safety of chronic cannabis-derived product use in children.
  • To explore data from randomized controlled trials, prenatal exposure, and adolescent use.

Main Methods:

  • Review of randomized controlled trials involving cannabidiol.
  • Examination of studies on prenatal cannabis exposure.
  • Analysis of research on adolescent cannabis use.

Main Results:

  • Methodological limitations (dosage, duration, co-addiction, genetics) hinder definitive conclusions.
  • Indirect evidence suggests potential negative and lasting effects on cognitive and behavioral functions.
  • Reported outcomes include externalizing behavioral problems and decreased IQ.

Conclusions:

  • No firm conclusions can be drawn due to study limitations.
  • Long-term data indicate possible adverse cognitive and behavioral effects.
  • Further large-scale, long-term studies in childhood epilepsy cohorts are essential.