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Related Experiment Videos

Vasoactive intestinal peptide (VIP) cells in the pancrease and gastro-intestinal mucosa. An immunohistochemical and

R Buffa, C Capella, E Solcia

    Histochemistry
    |January 24, 1977
    PubMed
    Summary
    This summary is machine-generated.

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    Vasoactive intestinal peptide (VIP) immunoreactive cells are present in the pancreas and gastrointestinal tract of dogs, guinea pigs, and humans. Their presence may explain pancreatic endocrine tumors that produce VIP.

    Area of Science:

    • Gastroenterology
    • Endocrinology
    • Immunohistochemistry

    Background:

    • Vasoactive intestinal peptide (VIP) is a peptide hormone with diverse physiological roles.
    • The distribution and function of VIP-producing cells in the pancreas and gastrointestinal tract are not fully elucidated.
    • Pancreatic endocrine tumors can secrete VIP, leading to specific clinical syndromes.

    Purpose of the Study:

    • To detect and characterize VIP-immunoreactive cells in the pancreas and gastrointestinal mucosa of various species.
    • To investigate the potential relationship between VIP cells and D1 cells.
    • To explore the implications of VIP cell presence in normal pancreas for the development of VIP-producing tumors.

    Main Methods:

    • Immunoperoxidase and immunofluorescence techniques were employed.

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  • Antibodies against pure porcine VIP were used for detection.
  • Tissues examined included pancreas (especially islets) and gastrointestinal mucosa from dogs, guinea pigs, and humans.
  • Ultrastructural analysis was performed to identify D1 cells.

    • Main Results:

    • VIP-immunoreactive cells were identified in the pancreas and gastrointestinal mucosa of all species studied.
    • These cells were widely distributed but not numerous at any specific site.
    • A parallelism was observed between VIP-immunoreactive cells and ultrastructurally identified D1 cells.
    • The findings suggest a potential link between VIP cells in normal pancreas and the pathogenesis of VIP-producing pancreatic endocrine tumors.

    Conclusions:

    • VIP-immunoreactive cells are a normal component of the pancreas and gastrointestinal tract in several mammalian species.
    • The co-localization with D1 cells suggests a potential functional relationship.
    • The presence of VIP cells in normal pancreatic tissue may contribute to understanding the origin of VIP-secreting pancreatic tumors.