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Systematic Review: Genetic Associations for Prognostic Factors of Urinary Bladder Cancer
Nadezda Lipunova1,2,3, Anke Wesselius2, Kar K Cheng4
1Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
Biomarkers in Cancer
|January 8, 2020
Summary
Germline genetic patterns for urinary bladder cancer (UBC) outcomes show limited overlap between different prognostic endpoints. This suggests distinct biological origins for UBC recurrence, progression, and death, impacting patient outcome prediction.
Area of Science:
- Genetics
- Oncology
- Cancer Research
Background:
- Germline genetic associations are known for urinary bladder cancer (UBC) outcomes and prognostic characteristics.
- The overlap in genetic patterns across various prognostic endpoints remains unclear.
Purpose of the Study:
- To review contemporary literature on genetic associations with UBC prognostic outcomes.
- To identify potential overlap in reported genes across different UBC prognostic endpoints.
Main Methods:
- Searched EMBASE, MEDLINE, and PubMed for relevant English-language articles.
- Summarized 112 studies, analyzing 316 single-nucleotide polymorphisms (SNPs) across prognostic outcomes and characteristics.
- Focused on common SNPs in OGG1, TP53, and MDM2.
Main Results:
- Considerable differences observed in genetic associations across studied UBC outcomes.
- SNPs in OGG1, TP53, and MDM2 were most frequently reported.
- Functional enrichment analysis for recurrence and death yielded different terms, suggesting separate biological mechanisms.
Conclusions:
- UBC prognostic outcomes may originate from different biological pathways with limited genetic overlap.
- Further validation is crucial for identifying phenotypes that predict patient outcomes and improve management.
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