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Comparison of renal arterial resistive index in type 2 diabetic nephropathy stage 0-4

Sharareh Sanei Sistani1, Ali Alidadi2, Alireza Ansari Moghadam3

  • 1Department of Radiology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.

European Journal of Translational Myology
|January 8, 2020
PubMed

Insights

Renal artery resistive index (RI) correlates with systolic blood pressure, microalbuminuria, and kidney function (GFR) in diabetic nephropathy patients. Higher systolic BP and albuminuria, and lower GFR, increase RI, indicating disease severity.

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Medical Imaging

Background:

  • Chronic kidney disease (CKD) is a growing global health concern, often leading to cardiovascular complications.
  • Diabetic nephropathy is a major cause of CKD, characterized by progressive renal impairment.
  • Renal artery resistive index (RI) reflects atherosclerotic changes in small renal vessels.

Purpose of the Study:

  • To evaluate the renal artery resistive index (RI) in patients with diabetic nephropathy stages 0-4.
  • To determine the correlation between RI and key clinical parameters: HbA1c, systolic blood pressure (SBP), diastolic blood pressure (DBP), albuminuria, and glomerular filtration rate (GFR).

Main Methods:

  • A cross-sectional study involving 100 diabetic nephropathy patients.
  • Renal artery RI was measured using Ultrasound Doppler.
  • Data on SBP, DBP, albuminuria, GFR, and HbA1c were collected from patient medical records.

Main Results:

  • Significant positive correlations were found between RI and SBP (p=0.04, R=0.75), microalbuminuria (P=0.001, R=0.67), and GFR (P=0.001, R=0.76).
  • No significant association was observed between RI and DBP (P=0.45, R=0.32) or HbA1c (P=0.56, R=0.43).
  • Increased SBP, albumin excretion, and disease severity were linked to higher RI values, while decreased GFR was also associated with elevated RI.

Conclusions:

  • Renal artery resistive index is a valuable indicator of disease severity in diabetic nephropathy.
  • RI is significantly influenced by systolic blood pressure, microalbuminuria, and glomerular filtration rate.
  • These findings highlight the utility of RI in assessing renal vascular health in diabetic kidney disease.

Keywords:
Chronic kidney diseaseDiabetic nephropathyRenal arterial resistive indexUltrasound Doppler renal resistive index

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