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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Immunodeficiency Diseases01:25

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Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
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Infection01:20

Infection

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When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
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Stages of Infection01:26

Stages of Infection

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Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
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Sexually Transmitted Infections01:26

Sexually Transmitted Infections

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Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
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Endocarditis II: Clinical Features of Infective Endocarditis01:25

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Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
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Deep Dermal Injection As a Model of Candida albicans Skin Infection for Histological Analyses
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Infections preceding the development of Dercum disease.

Karen Beltran1, Rita Wadeea1, Karen L Herbst1

  • 1College of Medicine, University of Arizona, 1625 N Campbell Ave, Tucson, Arizona, 85724, United States.

Idcases
|January 8, 2020
PubMed
Summary

Dercum Disease (DD), a rare condition causing painful fat masses, may be triggered by infections like Lyme disease. Prompt infection diagnosis and treatment could prevent further fat damage in DD patients.

Keywords:
CoccidioidomycosisDercum diseaseHistoplasmosisLyme diseaseToxoplasmosis

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Area of Science:

  • Dermatology
  • Rheumatology
  • Infectious Diseases

Background:

  • Dercum Disease (DD) is a rare inflammatory condition characterized by painful subcutaneous adipose tissue masses.
  • DD symptoms overlap with fibromyalgia, and its etiology remains unclear, with proposed links to metabolic, autoimmune, or genetic factors.
  • Alterations in lymphatic vessels are a known feature of Dercum Disease.

Observation:

  • This case series details seven patients where Dercum Disease onset followed an infection.
  • Identified preceding infections included histoplasmosis, coccidioidomycosis, and Lyme disease.
  • The study reviews known effects of infectious agents on adipose tissue.

Findings:

  • The presented cases suggest a potential link between specific infections and the development of Dercum Disease.
  • Infections may play a role in the pathogenesis of DD, contributing to the formation of painful lipomas.
  • The findings highlight the importance of considering infectious triggers in DD diagnosis.

Implications:

  • Early identification and management of infections preceding DD could be crucial.
  • Timely treatment of these infections may help mitigate or prevent the progression of Dercum Disease.
  • Further research into the infectious etiology of DD is warranted to improve patient outcomes.